RXFP2

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Relaksinu/insulinu-slična familija, peptidni receptor 2
Identifikatori
SimboliRXFP2; GPR106; GREAT; INSL3R; LGR8; LGR8.1
Vanjski IDOMIM: 606655 MGI: 2153463 HomoloGene: 15402 IUPHAR: RXFP2 GeneCards: RXFP2 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• proteinsko vezivanje
• aktivnost proteinskog-hormonskog receptora
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• G-proteinska signalizacija, put aktivacije adenilat ciklaze
• razvoj muških gonada
Ortolozi
VrstaČovekMiš
Entrez122042140498
EnsemblENSG00000133105ENSMUSG00000053368
UniProtQ8WXD0Q0VB90
RefSeq (mRNA)NM_130806NM_080468
RefSeq (protein)NP_570718NP_536716
Lokacija (UCSC)Chr 13:
31.21 - 31.28 Mb		Chr 5:
150.29 - 150.35 Mb
PubMed pretraga[1][2]

RXFP2, relaksinu/insulinu-slična familija, peptidni receptor 2, je humani G-protein spregnuti receptor.[1]

Vidi još

  • Relaksinski receptor

Reference

  1. ↑ „Entrez Gene: RXFP2 relaxin/insulin-like family peptide receptor 2”. 

Literatura

  • Bathgate RA, Ivell R, Sanborn BM, et al. (2005). „Receptors for relaxin family peptides.”. Ann. N. Y. Acad. Sci. 1041: 61–76. DOI:10.1196/annals.1282.010. PMID 15956688. 
  • Bathgate RA, Ivell R, Sanborn BM, et al. (2006). „International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.”. Pharmacol. Rev. 58 (1): 7–31. DOI:10.1124/pr.58.1.9. PMID 16507880. 
  • Hsu SY, Nakabayashi K, Nishi S, et al. (2002). „Activation of orphan receptors by the hormone relaxin.”. Science 295 (5555): 671–4. DOI:10.1126/science.1065654. PMID 11809971. 
  • Kumagai J, Hsu SY, Matsumi H, et al. (2002). „INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.”. J. Biol. Chem. 277 (35): 31283–6. DOI:10.1074/jbc.C200398200. PMID 12114498. 
  • Gorlov IP, Kamat A, Bogatcheva NV, et al. (2003). „Mutations of the GREAT gene cause cryptorchidism.”. Hum. Mol. Genet. 11 (19): 2309–18. DOI:10.1093/hmg/11.19.2309. PMID 12217959. 
  • Sudo S, Kumagai J, Nishi S, et al. (2003). „H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.”. J. Biol. Chem. 278 (10): 7855–62. DOI:10.1074/jbc.M212457200. PMID 12506116. 
  • Ferlin A, Simonato M, Bartoloni L, et al. (2003). „The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism.”. J. Clin. Endocrinol. Metab. 88 (9): 4273–9. DOI:10.1210/jc.2003-030359. PMID 12970298. 
  • Roh J, Virtanen H, Kumagai J, et al. (2004). „Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism.”. Reprod. Biomed. Online 7 (4): 400–6. DOI:10.1016/S1472-6483(10)61883-4. PMID 14656401. 
  • Vinci G, Anjot MN, Trivin C, et al. (2005). „An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia.”. J. Clin. Endocrinol. Metab. 89 (12): 6282–5. DOI:10.1210/jc.2004-0891. PMID 15579790. 
  • Büllesbach EE, Schwabe C (2005). „LGR8 signal activation by the relaxin-like factor.”. J. Biol. Chem. 280 (15): 14586–90. DOI:10.1074/jbc.M414443200. PMID 15708846. 
  • Muda M, He C, Martini PG, et al. (2005). „Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.”. Mol. Hum. Reprod. 11 (8): 591–600. DOI:10.1093/molehr/gah205. PMID 16051677. 
  • Rosengren KJ, Zhang S, Lin F, et al. (2006). „Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.”. J. Biol. Chem. 281 (38): 28287–95. DOI:10.1074/jbc.M603829200. PMID 16867980. 
  • Bogatcheva NV, Ferlin A, Feng S, et al. (2007). „T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.”. Am. J. Physiol. Endocrinol. Metab. 292 (1): E138–44. DOI:10.1152/ajpendo.00228.2006. PMID 16926383. 
  • Scott DJ, Layfield S, Yan Y, et al. (2007). „Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.”. J. Biol. Chem. 281 (46): 34942–54. DOI:10.1074/jbc.M602728200. PMID 16963451. 
  • El Houate B, Rouba H, Sibai H, et al. (2007). „Novel mutations involving the INSL3 gene associated with cryptorchidism.”. J. Urol. 177 (5): 1947–51. DOI:10.1016/j.juro.2007.01.002. PMID 17437853. 
  • Scott DJ, Wilkinson TN, Zhang S, et al. (2007). „Defining the LGR8 residues involved in binding insulin-like peptide 3.”. Mol. Endocrinol. 21 (7): 1699–712. DOI:10.1210/me.2007-0097. PMID 17473281. 

Spoljašnje veze

  • „Relaxin Family Peptide Receptors: RXFP2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)