F2RL3

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Proteazom-aktivirani receptor 4
Identifikatori
SimboliF2RL3; PAR4
Vanjski IDOMIM: 602779 MGI: 1298207 HomoloGene: 36148 IUPHAR: PAR4 GeneCards: F2RL3 Gene
Ontologija gena
Molekularna funkcija • rodopsinu-slična receptorska aktivnost
• receptorska aktivnost
• aktivnost trombinskog receptora
Celularna komponenta • membrana plazme
• integralno sa membranom plazme
Biološki proces • prenos signala
• G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom
• koagulacija krvi
• respons na ranjavanje
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez900214065
EnsemblENSG00000127533ENSMUSG00000050147
UniProtQ96RI0Q0VDX1
RefSeq (mRNA)NM_003950NM_007975
RefSeq (protein)NP_003941NP_032001
Lokacija (UCSC)Chr 19:
16.86 - 16.87 Mb		Chr 8:
75.66 - 75.66 Mb
PubMed pretraga[1][2]

Proteazom-aktivirani receptor 4 (PAR4), ili Receptoru koagulacionog faktora II (trombina) sličan 3, je protein kodiran F2RL3 genom kod ljudi.[1]

F2RL3 je član velike familije G-protein spregnutih receptora koji interaguju sa guanozin-nukleotid-vezujućim proteinima. PAR4 je takođe član familije proteazom aktiviranih receptora. On je aktiviran trombinom i tripsinom. Do aktivacije dolazi proteolitičkim odsecanjem njegovog ekstracelularnog amino terminusa. Novo-formirani amino terminus dejstvuje kao vezani ligand i aktivira receptor.[1]

Vidi još

  • Proteazom-aktivirani receptor

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3”. 

Literatura

  • Leger AJ, Covic L, Kuliopulos A (2006). „Protease-activated receptors in cardiovascular diseases.”. Circulation 114 (10): 1070–7. DOI:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995. 
  • Xu WF, Andersen H, Whitmore TE, et al. (1998). „Cloning and characterization of human protease-activated receptor 4.”. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. DOI:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465. 
  • Kahn ML, Zheng YW, Huang W, et al. (1998). „A dual thrombin receptor system for platelet activation.”. Nature 394 (6694): 690–4. DOI:10.1038/29325. PMID 9716134. 
  • Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). „Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.”. J. Biol. Chem. 273 (36): 23290–6. DOI:10.1074/jbc.273.36.23290. PMID 9722561. 
  • Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). „Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.”. J. Clin. Invest. 103 (6): 879–87. DOI:10.1172/JCI6042. PMC 408153. PMID 10079109. 
  • Andersen H, Greenberg DL, Fujikawa K, et al. (1999). „Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity.”. Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189–93. DOI:10.1073/pnas.96.20.11189. PMC 18009. PMID 10500152. 
  • Sambrano GR, Huang W, Faruqi T, et al. (2000). „Cathepsin G activates protease-activated receptor-4 in human platelets.”. J. Biol. Chem. 275 (10): 6819–23. DOI:10.1074/jbc.275.10.6819. PMID 10702240. 
  • Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). „PAR3 is a cofactor for PAR4 activation by thrombin.”. Nature 404 (6778): 609–13. DOI:10.1038/35007085. PMID 10766244. 
  • Miike S, McWilliam AS, Kita H (2002). „Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.”. J. Immunol. 167 (11): 6615–22. PMID 11714832. 
  • Asokananthan N, Graham PT, Fink J, et al. (2002). „Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.”. J. Immunol. 168 (7): 3577–85. PMID 11907122. 
  • Henriksen RA, Hanks VK (2002). „PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets.”. Arterioscler. Thromb. Vasc. Biol. 22 (5): 861–6. DOI:10.1161/01.ATV.0000014742.56572.25. PMID 12006403. 
  • Covic L, Singh C, Smith H, Kuliopulos A (2003). „Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.”. Thromb. Haemost. 87 (4): 722–7. PMID 12008957. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Owen WG (2003). „PAR-3 is a low-affinity substrate, high affinity effector of thrombin.”. Biochem. Biophys. Res. Commun. 305 (1): 166–8. DOI:10.1016/S0006-291X(03)00732-0. PMID 12732212. 
  • Adam F, Verbeuren TJ, Fauchère JL, et al. (2003). „Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.”. J. Thromb. Haemost. 1 (4): 798–804. DOI:10.1046/j.1538-7836.2003.00138.x. PMID 12871418. 
  • Wu CC, Hwang TL, Liao CH, et al. (2004). „The role of PAR4 in thrombin-induced thromboxane production in human platelets.”. Thromb. Haemost. 90 (2): 299–308. DOI:10.1267/THRO03020299. PMID 12888878. 
  • Kawai T, Akira S, Reed JC (2003). „ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.”. Mol. Cell. Biol. 23 (17): 6174–86. DOI:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339. 
  • Jacques SL, Kuliopulos A (2004). „Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.”. Biochem. J. 376 (Pt 3): 733–40. DOI:10.1042/BJ20030954. PMC 1223816. PMID 13678420. 
  • Han Y, Nurden A, Combrié R, Pasquet JM (2004). „Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.”. J. Thromb. Haemost. 1 (10): 2206–15. DOI:10.1046/j.1538-7836.2003.00436.x. PMID 14521606. 
  • „Protease-Activated Receptors: PAR4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-04-02. 
  • p
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)