Prokineticinski receptor 2

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Prokineticinski receptor 2
Identifikatori
SimboliPROKR2; KAL3; PKR2; GPR73L1; GPR73b; GPRg2; dJ680N4.3
Vanjski IDOMIM: 607123 MGI: 2181363 HomoloGene: 16368 IUPHAR: PKR2 GeneCards: PROKR2 Gene
Ontologija gena
Molekularna funkcija • rodopsinu-slična receptorska aktivnost
• receptorska aktivnost
• neuropeptid Y receptorska aktivnost
Celularna komponenta • membrana
• integralno sa membranom
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• cirkadijurni ritam
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez128674246313
EnsemblENSG00000101292ENSMUSG00000050558
UniProtQ8NFJ6Q6GTF8
RefSeq (mRNA)NM_144773NM_144944
RefSeq (protein)NP_658986NP_659193
Lokacija (UCSC)Chr 20:
5.23 - 5.24 Mb		Chr 2:
132.06 - 132.08 Mb
PubMed pretraga[1][2]

Prokineticinski receptor 2 (PKR2), je G-protein spregnuti receptor kodiran PROKR2 genom kod ljudi.[1]

Prokineticini su sekretivni proteini koji mogu da promovišu angiogenezu i da indukuju jake kontrakcije gastrointestinalnih glatkih mišića. Protein kodiran ovim genom je integralni membranski protein i G protein-spregnuti receptor za prokineticine. Ovaj protein je sličan po aminokiselinskoj sekvenci sa GPR73, koji je takođe G protein-spregnuti receptor za prokineticine.[1]

Vidi još

  • Prokineticinski receptor
  • Kalmanov sindrom

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: PROKR2 prokineticin receptor 2”. 

Literatura

  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052. 
  • Lin DC, Bullock CM, Ehlert FJ, et al. (2002). „Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.”. J. Biol. Chem. 277 (22): 19276–80. DOI:10.1074/jbc.M202139200. PMID 11886876. 
  • Soga T, Matsumoto S, Oda T, et al. (2003). „Molecular cloning and characterization of prokineticin receptors.”. Biochim. Biophys. Acta 1579 (2-3): 173–9. PMID 12427552. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Battersby S, Critchley HO, Morgan K, et al. (2004). „Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.”. J. Clin. Endocrinol. Metab. 89 (5): 2463–9. DOI:10.1210/jc.2003-032012. PMID 15126578. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Pasquali D, Rossi V, Staibano S, et al. (2006). „The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy.”. Endocrinology 147 (9): 4245–51. DOI:10.1210/en.2006-0614. PMID 16763065. 
  • Dodé C, Teixeira L, Levilliers J, et al. (2006). „Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.”. PLoS Genet. 2 (10): e175. DOI:10.1371/journal.pgen.0020175. PMC 1617130. PMID 17054399. 
  • „Prokineticin Receptors: PKR2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2009-07-17.