FZD1

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Uvojiti receptor 1
Identifikatori
SimboliFZD1; DKFZp564G072; FLJ95923
Vanjski IDOMIM: 603408 MGI: 1196625 HomoloGene: 20750 IUPHAR: FZD1 GeneCards: FZD1 Gene
Ontologija gena
Molekularna funkcija • aktivnost G protein spregnutog receptora
• receptorsko vezivanje
• proteinsko vezivanje
• Wnt proteinsko vezivanje
• vezivanje PDZ domena
Celularna komponenta • citoplazma
• ćelijska površina
• integralno sa membranom
• sinaptosom
• membrana neuronske projekcije
Biološki proces • pozitivna regulacija proteinske fosforilacije
• razvoj vaskulature
• morfogeneza odlivnog trakta
• signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez832114362
EnsemblENSG00000157240ENSMUSG00000044674
UniProtQ9UP38O70421
RefSeq (mRNA)NM_003505.1NM_021457.3
RefSeq (protein)NP_003496.1NP_067432.2
Lokacija (UCSC)Chr 7:
90.89 - 90.9 Mb		Chr 5:
4.75 - 4.76 Mb
PubMed pretraga[1][2]

Uvojiti-1 je protein koji je kod ljudi kodiran FZD1 genom.[1][2]

Članovi familije 'uvojitih' proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD1 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. FZD1 transkript je izražen u različitim tkivima.[2]

Reference

  1. ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun 252 (1): 117–22. DOI:10.1006/bbrc.1998.9607. PMID 9813155. 
  2. ↑ 2,0 2,1 „Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)”. 

Literatura

  • Tanaka S, Akiyoshi T, Mori M, et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. 
  • Gazit A, Yaniv A, Bafico A, et al. (1999). „Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.”. Oncogene 18 (44): 5959–66. DOI:10.1038/sj.onc.1202985. PMID 10557084. 
  • DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (2002). „The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor.”. Naunyn Schmiedebergs Arch. Pharmacol. 365 (5): 341–8. DOI:10.1007/s00210-002-0540-3. PMID 12012019. 
  • Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.”. FEBS Lett. 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. PMID 12067714. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948. 
  • Zilberberg A, Yaniv A, Gazit A (2004). „The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway”. J. Biol. Chem. 279 (17): 17535–42. DOI:10.1074/jbc.M311292200. PMID 14739301. 
  • Wu J, Klein TJ, Mlodzik M (2006). „Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity”. PLoS Biol. 2 (7): E158. DOI:10.1371/journal.pbio.0020158. PMC 449784. PMID 15252441. 
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Yang L, Yamasaki K, Shirakata Y, et al. (2006). „Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes”. J. Dermatol. Sci. 42 (2): 111–9. DOI:10.1016/j.jdermsci.2005.12.011. PMID 16442268. 

Vidi još

Spoljašnje veze

  • „Frizzled Receptors: FZD1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)