Tronbina

Identifikadoreak
Taxoia	Homo sapiens
Kokapena
Hasiera	^[1]
Amaiera	^[2]
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Transkripzioak
Ontologia
Funtzio-molekularrak	Ikusi kaltzio ioi lotura signaling receptor binding ^(en) peptidase activity ^(en) hydrolase activity ^(en) growth factor activity ^(en) serine-type peptidase activity ^(en) thrombospondin receptor activity ^(en) proteina lotura serine-type endopeptidase activity ^(en) lipopolysaccharide binding ^(en) heparin binding ^(en) enzyme activator activity ^(en) serine-type endopeptidase activity ^(en)
Osagai-zelularra	Ikusi extracellular exosome ^(en) blood microparticle ^(en) endoplasmic reticulum lumen ^(en) Golgi lumen ^(en) zelula mintz zelulaz kanpoko eremu extracellular space ^(en) external side of plasma membrane ^(en) extracellular space ^(en) collagen-containing extracellular matrix ^(en) extracellular exosome ^(en) blood microparticle ^(en)
Prozesu-biologikoak	Ikusi blood coagulation, intrinsic pathway ^(en) regulation of blood coagulation ^(en) positive regulation of phosphatidylinositol 3-kinase signaling ^(en) positive regulation of collagen biosynthetic process ^(en) izaki zelulanitzen garapena peptidyl-glutamic acid carboxylation ^(en) acute-phase response ^(en) positive regulation of reactive oxygen species metabolic process ^(en) endoplasmic reticulum to Golgi vesicle-mediated transport ^(en) positive regulation of cell growth ^(en) cell surface receptor signaling pathway ^(en) gene-erregulazio positive regulation of release of sequestered calcium ion into cytosol ^(en) positive regulation of cell population proliferation ^(en) leukocyte migration ^(en) negative regulation of fibrinolysis ^(en) positive regulation of blood coagulation ^(en) regulation of cytosolic calcium ion concentration ^(en) response to wounding ^(en) signal peptide processing ^(en) positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ^(en) regulation of cell shape ^(en) Hemostasi negative regulation of proteolysis ^(en) negative regulation of platelet activation ^(en) negative regulation of astrocyte differentiation ^(en) positive regulation of protein phosphorylation ^(en) Fibrinolisi Gatzapen proteolisi platelet activation ^(en) positive regulation of protein localization to nucleus ^(en) positive regulation of lipid kinase activity ^(en) regulation of complement activation ^(en) antimicrobial humoral immune response mediated by antimicrobial peptide ^(en) negative regulation of cytokine production involved in inflammatory response ^(en) regulation of signaling receptor activity ^(en) G proteina errezeptore akoplatuaren komunikazio bidea positive regulation of receptor signaling pathway via JAK-STAT ^(en) blood coagulation, fibrin clot formation ^(en)

Tronbina odolaren gatzapen prozesuan parte hartzen duen funtsezko entzima da. Prozesu horretan fibrinogeno izeneko proteina disolbagarria fibrina izeneko proteina disolbaezina bihurtzen da, tronbina izanik bilakaera hori katalizatzen duen entzima.

Fibrinogeno → Fibrina

Tronbina 36 eta 259 aminoazido dituzten bi kate polipeptidikoz osaturik dago. Bi kate horiek lotura disulfurikoen bidez elkarturik daude.

Tronbina protronbina izeneko molekula batetik sortzen da. Bilakaera horretan parte hartzen duen entzima tronboplastina da, odoleko plaketek askatzen dutena odol-hodi batek kalte handia jasotzen duenean. Tronbina sortzeko prozesuan K bitaminak eta kaltzio ioiek funtsezko zeregina burutzen dute.

Tronbinari esker sortzen den fibrina odol-koaguluaren sortzailea da, odoljarioak ekiditen dituena.

Erreferentziak

↑ GRCh38: Ensembl release 89:. Ensembl.
↑ GRCh38: Ensembl release 89:. Ensembl.

Kanpo estekak

Autoritate kontrola	Wikimedia proiektuak Datuak: Q409166 Multimedia: Thrombin / Q409166 Identifikadoreak BNF: 12316045k (data) LCCN: sh85135066 Medikuntzako identifikadoreak MeSH: D013917 Kimikako identifikadoreak ATC: B02BC06 UNII: 25ADE2236L