SEMA4F

Protein-coding gene in the species Homo sapiens
SEMA4F
Identifiers
AliasesSEMA4F, M-SEMA, PRO2353, S4F, SEMAM, SEMAW, m-Sema-M, ssemaphorin 4F
External IDsOMIM: 603706; MGI: 1340055; HomoloGene: 3147; GeneCards: SEMA4F; OMA:SEMA4F - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SEMA4F
Genomic location for SEMA4F
Band2p13.1Start74,654,228 bp[1]
End74,683,853 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for SEMA4F
Genomic location for SEMA4F
Band6 C3|6 35.94 cMStart82,888,866 bp[2]
End82,916,750 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • middle temporal gyrus

  • prefrontal cortex

  • gonad

  • testicle

  • superior frontal gyrus

  • sural nerve

  • right frontal lobe

  • postcentral gyrus

  • Brodmann area 23
Top expressed in
  • trigeminal ganglion

  • substantia nigra

  • ventromedial nucleus

  • lumbar spinal ganglion

  • perirhinal cortex

  • entorhinal cortex

  • condyle

  • CA3 field

  • primary motor cortex

  • arcuate nucleus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • neuropilin binding
  • semaphorin receptor binding
  • chemorepellent activity
Cellular component
  • integral component of membrane
  • postsynaptic membrane
  • membrane
  • plasma membrane
  • synapse
  • integral component of plasma membrane
  • endoplasmic reticulum
  • extracellular space
  • postsynaptic density
  • cell junction
  • dendrite
  • cell projection
  • perikaryon
Biological process
  • cell differentiation
  • cell-cell signaling
  • nervous system development
  • axon guidance
  • multicellular organism development
  • negative regulation of axon extension
  • retinal ganglion cell axon guidance
  • negative chemotaxis
  • neural crest cell migration
  • positive regulation of cell migration
  • negative regulation of axon extension involved in axon guidance
  • semaphorin-plexin signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10505

20355

Ensembl

ENSG00000135622

ENSMUSG00000000627

UniProt

O95754

Q9Z123

RefSeq (mRNA)

NM_001271661
NM_001271662
NM_004263

NM_001113481
NM_011350
NM_001308374

RefSeq (protein)

NP_001258590
NP_001258591
NP_004254

NP_001295303
NP_035480

Location (UCSC)Chr 2: 74.65 – 74.68 MbChr 6: 82.89 – 82.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Semaphorin-4F is a protein that in humans is encoded by the SEMA4F gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135622 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000627 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Encinas JA, Kikuchi K, Chedotal A, de Castro F, Goodman CS, Kimura T (March 1999). "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2491–6. Bibcode:1999PNAS...96.2491E. doi:10.1073/pnas.96.5.2491. PMC 26812. PMID 10051670.
  6. ^ "Entrez Gene: SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F".

Further reading

  • Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (November 1998). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi:10.1016/S0896-6273(00)80625-X. PMID 9856463.
  • Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Schultze W, Eulenburg V, Lessmann V, Herrmann L, Dittmar T, Gundelfinger ED, Heumann R, Erdmann KS (August 2001). "Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95". Journal of Neurochemistry. 78 (3): 482–9. doi:10.1046/j.1471-4159.2001.00447.x. PMID 11483650.
  • Francks C, Fisher SE, Olson RK, Pennington BF, Smith SD, DeFries JC, Monaco AP (March 2002). "Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1". Psychiatric Genetics. 12 (1): 35–41. doi:10.1097/00041444-200203000-00005. hdl:11858/00-001M-0000-0012-C9C5-5. PMID 11901358. S2CID 15050388.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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