MGST3

Protein-coding gene in the species Homo sapiens
MGST3
Identifiers
AliasesMGST3, GST-III, microsomal glutathione S-transferase 3
External IDsOMIM: 604564; MGI: 1913697; HomoloGene: 3327; GeneCards: MGST3; OMA:MGST3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MGST3
Genomic location for MGST3
Band1q24.1Start165,631,213 bp[1]
End165,661,796 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for MGST3
Genomic location for MGST3
Band1|1 H2.3Start167,199,535 bp[2]
End167,221,410 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • jejunal mucosa

  • Skeletal muscle tissue of rectus abdominis

  • pons

  • right ventricle

  • thoracic diaphragm

  • apex of heart

  • duodenum

  • Skeletal muscle tissue of biceps brachii

  • mucosa of sigmoid colon
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • mucous cell of stomach

  • epithelium of stomach

  • pyloric antrum

  • olfactory epithelium

  • digastric muscle

  • temporal muscle

  • right ventricle

  • interventricular septum

  • duodenum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • protein binding
  • glutathione transferase activity
  • leukotriene-C4 synthase activity
  • glutathione peroxidase activity
  • oxidoreductase activity
  • lyase activity
Cellular component
  • integral component of membrane
  • organelle membrane
  • extracellular exosome
  • endoplasmic reticulum membrane
  • nuclear envelope
  • endoplasmic reticulum
  • membrane
  • intracellular membrane-bounded organelle
Biological process
  • xenobiotic metabolic process
  • glutathione derivative biosynthetic process
  • response to organonitrogen compound
  • cellular oxidant detoxification
  • lipid metabolism
  • leukotriene biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4259

66447

Ensembl

ENSG00000143198

ENSMUSG00000026688

UniProt

O14880

Q9CPU4

RefSeq (mRNA)

NM_004528

NM_025569
NM_029392

RefSeq (protein)

NP_004519

NP_079845

Location (UCSC)Chr 1: 165.63 – 165.66 MbChr 1: 167.2 – 167.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.[5][6]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143198 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026688 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (Oct 1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J Biol Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.
  6. ^ a b "Entrez Gene: MGST3 microsomal glutathione S-transferase 3".

Further reading

  • Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
  • Kobayashi K, Xin Y, Ymer SI, et al. (2007). "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells". Brain Res. 1170: 129–39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568. S2CID 31320196.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Thameem F, Yang X, Permana PA, et al. (2003). "Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians". Hum. Genet. 113 (4): 353–8. doi:10.1007/s00439-003-0980-y. PMID 12898215. S2CID 105953.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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