DCC1

Protein-coding gene in the species Homo sapiens
DSCC1
Identifiers
AliasesDSCC1, DCC1, DNA replication and sister chromatid cohesion 1
External IDsOMIM: 613203; MGI: 1919357; HomoloGene: 5464; GeneCards: DSCC1; OMA:DSCC1 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for DSCC1
Genomic location for DSCC1
Band8q24.12Start119,833,976 bp[1]
End119,855,894 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for DSCC1
Genomic location for DSCC1
Band15|15 D1Start54,939,495 bp[2]
End54,953,887 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • gonad

  • parotid gland

  • testicle

  • buccal mucosa cell

  • ventricular zone

  • embryo

  • ganglionic eminence

  • hair follicle

  • tendon of biceps brachii
Top expressed in
  • hand

  • ureter

  • otic vesicle

  • primary oocyte

  • endocardial cushion

  • abdominal wall

  • vas deferens

  • medial ganglionic eminence

  • seminiferous tubule

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • single-stranded DNA helicase activity
  • DNA binding
  • DNA clamp loader activity
Cellular component
  • nucleoplasm
  • nucleus
  • chromosome, centromeric region
  • chromatin
  • Ctf18 RFC-like complex
Biological process
  • maintenance of mitotic sister chromatid cohesion
  • cell cycle
  • DNA replication
  • regulation of DNA replication
  • post-translational protein acetylation
  • positive regulation of DNA-directed DNA polymerase activity
  • mitotic sister chromatid cohesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79075

72107

Ensembl

ENSG00000136982

ENSMUSG00000022422

UniProt

Q9BVC3

Q14AI0

RefSeq (mRNA)

NM_024094

NM_183089
NM_001355594

RefSeq (protein)

NP_076999

NP_898912
NP_001342523

Location (UCSC)Chr 8: 119.83 – 119.86 MbChr 15: 54.94 – 54.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sister chromatid cohesion protein DCC1 is a protein that in humans is encoded by the DSCC1 gene.[5][6]

Interactions

DCC1 has been shown to interact with CHTF18.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136982 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022422 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
  6. ^ "Entrez Gene: DCC1 defective in sister chromatid cohesion homolog 1 (S. cerevisiae)".
  7. ^ Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
  8. ^ Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.

Further reading

  • Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  • Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. Bibcode:2003PNAS..10010237B. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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