CLTB

CLTB
Identifiers
Aliases	CLTB, LCB, clathrin light chain B
External IDs	OMIM: 118970; MGI: 1921575; HomoloGene: 37532; GeneCards: CLTB; OMA:CLTB - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 176,392,501 bp[1] End 176,416,539 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 54,740,214 bp[2] End 54,759,157 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen gingival epithelium apex of heart mucosa of transverse colon gastrocnemius muscle right auricle left ventricle right frontal lobe muscle of thigh Top expressed in neural layer of retina lip superior frontal gyrus dentate gyrus of hippocampal formation granule cell cerebellar cortex muscle of thigh esophagus primary visual cortex anterior horn of spinal cord skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function clathrin heavy chain binding peptide binding protein binding structural molecule activity Cellular component ciliary membrane clathrin-coated pit clathrin coat of trans-Golgi network vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle clathrin coat of coated pit intracellular membrane-bounded organelle trans-Golgi network clathrin vesicle coat clathrin coat plasma membrane cytosol synaptic vesicle membrane clathrin-coated endocytic vesicle presynaptic endocytic zone membrane postsynaptic endocytic zone cytoplasmic component Biological process clathrin-dependent endocytosis vesicle-mediated transport intracellular protein transport membrane organization clathrin coat assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1212 74325 Ensembl ENSG00000175416 ENSMUSG00000047547 UniProt P09497 Q6IRU5 RefSeq (mRNA) NM_001834 NM_007097 NM_001364126 NM_001364127 NM_028870 NM_001347512 RefSeq (protein) NP_001825 NP_009028 NP_001351055 NP_001351056 NP_001825.1 NP_001334441 NP_083146 Location (UCSC) Chr 5: 176.39 – 176.42 Mb Chr 13: 54.74 – 54.76 Mb PubMed search [3] [4]
Wikidata
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Clathrin, light chain B is a protein in humans that is encoded by the CLTB gene.^[5]

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and coated vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

References

Further reading